H2N2V1, 1968, Analysis, bibRecord, 000182

A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity

Identifieur interne : 000182 ( 1968/Analysis ); précédent : 000181; suivant : 000183

A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity

Auteurs : A. Clark ; C. W. Potter ; R. Jennings ; J. P. Nicholl ; A. F. Langrick [Royaume-Uni] ; G. C. Schild ; J. M. Wood ; D. A. J. Tyrrell

Source :

Journal of Hygiene [ 0022-1724 ] ; 1983-06.

RBID : ISTEX:17AB2A8F735A009E850C3C45FB0BE450F917DDB5

Abstract

Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.

Url:

DOI: 10.1017/S0022172400028989

Affiliations:

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ISTEX:17AB2A8F735A009E850C3C45FB0BE450F917DDB5

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<front><div type="abstract">Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.</div>
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A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity

A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity

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